The Inhibition of Two Steroid-activated Nicotinamide-adenine Dinucleotide (phosphate) Transhydrogenases by Folic Acid and Folic Acid Antimetabolites.
نویسندگان
چکیده
1. It was found that steroid-mediated nicotinamide-adenine dinucleotide (phosphate) transhydrogenases can be inhibited in vitro by folic acid and its antimetabolites. The most potent inhibitor was methotrexate, a drug with a high therapeutic index against experimental cancer. 2. The inhibitions produced by a combination of folic acid and the analogues were additive, as were those between the folic acid compounds and antagonistic steroid hormones.
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عنوان ژورنال:
- The Biochemical journal
دوره 94 شماره
صفحات -
تاریخ انتشار 1965