The Inhibition of Two Steroid-activated Nicotinamide-adenine Dinucleotide (phosphate) Transhydrogenases by Folic Acid and Folic Acid Antimetabolites.
نویسندگان
چکیده
1. It was found that steroid-mediated nicotinamide-adenine dinucleotide (phosphate) transhydrogenases can be inhibited in vitro by folic acid and its antimetabolites. The most potent inhibitor was methotrexate, a drug with a high therapeutic index against experimental cancer. 2. The inhibitions produced by a combination of folic acid and the analogues were additive, as were those between the folic acid compounds and antagonistic steroid hormones.
منابع مشابه
Identification of the radicals formed in the reactions of some endogenous photosensitizers with oleic acid under the UVA irradiation
Electron spin resonance measurements were performed for the reactions of some endogenous photosensitizers (flavin mononucleotide or flavin adenine dinucleotide or folic acid or β-nicotinamide adenine dinucleotide or β-nicotinamide adenine dinucleotide phosphate or pyridoxal-5'-phosphate or urocanic acid) with oleic acid under the ultraviolet light A irradiation using α-(4-pyridyl-1-oxide)-N-ter...
متن کاملNaturally Occurring Forms of Folic Acid
Previously (1, 6), it was shown that prefolic A, in crude form, was converted to N5-formyltetrahydrofolic acid by two separate enzymatic reactions. First, in the presence of a suitable electron acceptor, prefolic A is converted to tetrahydrofolic acid by a flavin adenine dinucleotide-linked enzyme system. Then, in the presence of transformylase and formyl-L-glutamate, tetrahydrofolic acid is fo...
متن کاملInhibition of Drought Stress Using Folic Acid in Kentucky bluegrass (Poa pratensis L.) under in vitro culture
Considering the high water requirement of grass during growth stages and the limitation of irrigation sources, it is important to find a suitable way to reduce the water requirement of the lawns as cover plants used in the Landscape. The purpose of this study was to investigate the effect of 2,4,5-T on the induction of callus from the hypocotyl explant in Kentucky bluegrass, induce in vitro dro...
متن کاملThe effect of ethanol and its metabolites on carbohydrate, protein, and lipid metabolism.
The metabolic effects of ethanol are due to a direct action of ethanol or its metabolites, changes in the redox state occurring during its metabolism, and modifications of the effects of ethanol by several nutritional factors. Ethanol causes hyperglycemia or hypoglycemia depending whether or not glycogen stores are adequate, inhibits protein synthesis, and results in a fatty liver and elevation...
متن کاملVerifying of Participation of Nitric Oxide in Morphine Place Conditioning in the Rat Medial Septum Using Nicotinamide Adenine Dinucleotide Phosphate-Diaphorase (NADPH-d)
Background: Role of nitric oxide (NO) in morphine-induced conditioned place preference (CPP) has already been proposed in the rat medial septum (MS), but no molecular evidence has been provided to clear this fact. Methods: Effects of intraseptal injections of L-arginine and/or NG-nitro-L-arginine methyl ester (L-NAME) on morphine place conditioning in Wistar rats were examined. Morphine (2.5-7....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Biochemical journal
دوره 94 شماره
صفحات -
تاریخ انتشار 1965